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The HPhos, founded on 2015 with the coordination and the support of PRAXI Network, is the first and largest cluster of knowledge-intensive enterprises and research organisations in the broader filed of Photonics and its related applications. HPhos aims to cluster all Greek entrepreneurial, industrial and academic players in order to create a hotbed for the development of new ideas and innovative products and services for industrial manufacturing & automation, telecoms, defense & security, cultural heritage, food, health, environment, energy efficiency and conversion. The Hellenic Photonics Cluster (HPhos) comprises approximately 20 innovative enterprises active in diverse areas of Photonics related Technologies, supported by a talented academic community in the field. A milestone for the creation of HPhos and its later development is the development of the Greek technology platform PhotonicsGR by the Foundation for Research and Technology – Hellas, as an active member of the European Technology Platform Photonics21.